AS affects quality of life in terms of reduced ability to work, Anxiety, Depression, Social isolation. If left untreated, chronic inflammation can ultimately cause the vertebrae in your spine to fuse together. You may have decreased range of motion when bending, twisting, or turning. You may also have greater, more frequent back pain. Spine and vertebrae inflammation can spread to other joints, including your hips, shoulders, and ribs. The inflammation may affect the tendons and ligaments that connect to your bones. In some cases, the inflammation can spread to organs, such as your bowel or even your lungs.